What is the difference between the lagging strand and the leading strand in a replication fork? Explain, with the help of a diagram, how both the leading strand and the lagging strand can be synthesized simultaneously by a DNA pol III complex when the two template strands are anti-parallel. Draw a replication fork showing how this occurs. Show/label DNA pol III, the leading strand, the Okazaki fragments, the RNA primers, helicase, single stranded binding protein and ligase. Indicate the direction of the replication fork migration, which is the same as that of the polymerase complex.
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