Sepsis One of the most fascinating disruptions of body functions is sepsis.

2022-06-02 18:17:38Sepsis
One of the most fascinating disruptions of body functions is
Place your order now for a similar assignment and have exceptional work written by our team of experts, At affordable ratesFor This or a Similar Paper Click To Order NowSepsisOne of the most fascinating disruptions of body functions issepsis. Sepsis is an overwhelming infection that sets off a cascade ofinflammation leading to multisystem organ failure. Dysregulation of bodysystems occurs, and organ dysfunction follows. Sepsis protocols help toidentify at-risk individuals and interventions occur to help preventlife-threatening complications. As an ICU nurse sepsis is a dailyoccurrence in our patient population. Understanding pharmacodynamics andpharmacokinetics alterations in sepsis can help direct medical intervention tohelp treat the massive infection. InterventionOnce sepsis is suspected, treatments must be quickly addressedbefore the patient’s body is further compromised. Sepsis triggers arehypotension, tachycardia, fever, tachypnea, and difficulty breathing. Rapid intervention is necessary. Blood cultures (to isolate possible bacteria)prior to antibiotic administration, fluid resuscitation, supplemental oxygenwhen necessary, and lactic acid levels should be assessed. Antibioticsshould not be delayed due to the aggressive nature of sepsis (Centers forDisease Control and Prevention, 2021). Antibiotic therapy is vital forsepsis infections and multiple antibiotics will be started until a source isdiscovered. PharmacokineticsA patient is admitted to the ICU with severer sepsis from unknownorigin and started on broad spectrum antibiotics. She is young andhealthy at baseline with no known health comorbidities. She is intubateddue to severe acidosis, pH at 7.0. She is on vasopressors with minimalpositive effects, her lactic acid level is 4, and she is unresponsive. Although she is started on multiple antibiotics she continues to declinehemodynamically. The pharmacokinetics of drug efficacy is altered due toher body’s ability to function properly. Drug metabolism is disrupted dueto multisystem organ failure and plasma dysfunction. Thesevere inflammatory response (release of cytokines, proteases, and otherinflammatory products) is causing capillary leakage and secondaryhypovolemia. As hypotension and hypovolemia worsen her acidosis increasesand her organ begin to shut down. Acidosis will further dysfunction ofher organs and how her body metabolizes medication. Endothelial damageallows disruption of intravascular fluids (antibiotics included) Shock liverand acute kidney injury further decreases excretion and metabolism ofantibiotics (like vancomycin). PharmacodynamicsThe dysfunction in her body led to unpredictablehemodynamics. Her body did not react to medications as desired due tosepsis. Alteration in pH changes the permeability of cells and plasma levels.Drugs have a half-life and without proper metabolism and excretion, there couldbe a potentially dangerous build-up within her body. The half-life ofmedications helps determine intervals of doses (Rosenthal & Burchum,2021). Vancomycin is one medication septic patients may be put on withinitial intervention. As her kidney function decreased, vancomycinlevels increased warranting dosing adjustments to prevent further damage. Plasma levels of these potentially harmful antibiotics were closely monitoreduntil a specific bacterium was isolated and therapy could bediscontinued. Plan of CareForthis specific patient, the plan of care was vastly dependent on herresponse. Correction of her acidosis and antibiotic treatments helped herbody begin to regain functionality. Her kidneys were acutely injuredrequiring continuous renal replacement therapy. As the metabolic acidosiswas corrected and excessive medication that was not metabolized (due to organdysfunction) was cleared she finally began to regain hemostasis. Capillary leakage stopped, kidneys began producing urine and clearing wasteproducts, and her vital signs stabilized. Her plan of care wascontinually adjusted as the bacterium was isolated and treatment could be targetedmore effectively. ReferencesCenters for Disease Controland Prevention. (2021, August 10). How is sepsis diagnosed and treated? Centersfor Disease Control and Prevention. Retrieved March 2, 2022, from, M., & Thompson, J. P. (2019). Pharmacokinetics insepsis. BJA education, 19(1), 7–13., L. D., & Burchum, J. R. (2021). Lehne’s pharmacotherapeuticsfor advanced practice nurses and physician assistants (2nd ed.) St. Louis, MO:Elsevier.FYI:It would be great to use different articles for refernces.For This or a Similar Paper Click To Order NowRelated
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