A patient has developed heparin-induced thrombocytopenia (HIT). While planning an explanation of…

A patient has developed
heparin-induced thrombocytopenia (HIT). While planning an explanation of this
disorder for the patient, the nurse considers which pathophysiology?

1. Activation of cytokines (such as
interleukins) by heparin resulting in inappropriate activation of the
coagulation cascade 2. Formation of platelet-heparin-PF4 complexes that trigger
increased levels of fibrinogen in the blood 3. Activation of platelets by
heparin-Fc receptor complexes resulting in prothrombotic activity 4. Formation
of antibody-heparin-PF4 complexes with subsequent activation of platelets by
the

A patient has developed
heparin-induced thrombocytopenia (HIT). While planning an explanation of this
disorder for the patient, the nurse considers which pathophysiology?

1. Activation of cytokines (such as
interleukins) by heparin resulting in inappropriate activation of the
coagulation cascade 2. Formation of platelet-heparin-PF4 complexes that trigger
increased levels of fibrinogen in the blood 3. Activation of platelets by
heparin-Fc receptor complexes resulting in prothrombotic activity 4. Formation
of antibody-heparin-PF4 complexes with subsequent activation of platelets by
the antibody portion of the complexes

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