A 69-year-old m an recently diagnosed w ith a Proteus m irabilis infection started treatm ent w ith a daily intram uscular injection of gentam icin. W hich of the follow ing pairs of properties best explains w hy the drug is usually adm inistered once daily despite the short half-life of gentam icin (about 2 hours)? A. Tim e-dependent killing and bactericidal e ect B. Extensive plasm a protein binding and bactericidal e ect C. Concentration-dependent killing and bacteriostatic e ect D. Concentration-dependent killing and long postantibiotic e ect E. Tim e-dependent killing and long postantibiotic e ect
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