A 66-year-old wom an com plained to her physician of urinary urgency and burning pain during…

A 66-year-old wom an com plained to her
physician of urinary urgency and burning pain during urination. A urine culture
revealed that Escherichia coli was the o ending organism , and a susceptibility
test showed that the bacterium w as resistant to am inoglycoside antibiotics. W
hich of the follow ing m echanism s can account for the bacterial resistance to
am inoglycosides?

A. Plasm
id-m ediated production of bacterial transferases

B. Decreased
a nit y of the drug for the 50S ribosom al subunit

C.

A 66-year-old wom an com plained to her
physician of urinary urgency and burning pain during urination. A urine culture
revealed that Escherichia coli was the o ending organism , and a susceptibility
test showed that the bacterium w as resistant to am inoglycoside antibiotics. W
hich of the follow ing m echanism s can account for the bacterial resistance to
am inoglycosides?

A. Plasm
id-m ediated production of bacterial transferases

B. Decreased
a nit y of the drug for the 50S ribosom al subunit

C. Developm
ent of an active e ux pum p

D. Mutation-induced
change of bacterial peroxidase

E. Mutation-induced
change of bacterial topoisom erases

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