A 65-year-old man presents to the dermatology clinic with a complaint of blisters developing on his.

A 65-year-old man presents to the dermatology clinic with a
complaint of blisters developing on his abdomen and extremities over the past
week. The lesions consisted initially of red patches followed by blister
formation. They are pruritic but not painful. The patient has no other
complaints and denies mucous membrane involvement. Examination shows only
multiple large, tense blisters with an erythematous base over the lower trunk
and extremities. The clinical picture is felt to be most consistent with bullous
pemphigoid.

Questions

A. Why is this condition called bullous pemphigoid?

B.
View complete question »

A 65-year-old man presents to the dermatology clinic with a
complaint of blisters developing on his abdomen and extremities over the past
week. The lesions consisted initially of red patches followed by blister
formation. They are pruritic but not painful. The patient has no other
complaints and denies mucous membrane involvement. Examination shows only
multiple large, tense blisters with an erythematous base over the lower trunk
and extremities. The clinical picture is felt to be most consistent with bullous
pemphigoid.

Questions

A. Why is this condition called bullous pemphigoid?

B. What would one expect histologic examination to show?

C. What would one expect to find on direct
immunofluorescence microscopy?

D. What is the presumed mechanism by which blister formation
occurs in bullous pemphigoid?

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