A 59-year-old wom an had been su ering from Parkinson disease for 4 years. Her disease was well…

A 59-year-old wom an had been su ering from
Parkinson disease for 4 years. Her disease was well controlled w ith a therapy
that included levodopa/carbidopa. W hich of the follow ing actions m ost likely
m ediated the therapeutic e – cacy of carbidopa in the patients disease?

A. Decreased
dopam ine m etabolism in the striatum

B. Increased
active transport of dopam ine into the brain

C. Increased
peripheral biotransform ation of dopam ine

D. Decreased
peripheral

A 59-year-old wom an had been su ering from
Parkinson disease for 4 years. Her disease was well controlled w ith a therapy
that included levodopa/carbidopa. W hich of the follow ing actions m ost likely
m ediated the therapeutic e – cacy of carbidopa in the patients disease?

A. Decreased
dopam ine m etabolism in the striatum

B. Increased
active transport of dopam ine into the brain

C. Increased
peripheral biotransform ation of dopam ine

D. Decreased
peripheral biotransform ation of levodopa

E. Decreased
levodopa reuptake in the striatum

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