A 49-year-old wom an on vacation in the south of Italy presented w ith fever, headache, and a sm…

A 49-year-old wom an on vacation in the
south of Italy presented w ith fever, headache, and a sm all, buttonlike skin
ulcer, 5 m m (about 0.2 inch) in diam eter, w ith a black center. The diagnosis
of Mediterranean spotted fever was m ade, and the wom an was prescribed
doxycycline. Which of the follow ing m olecular actions m ost likely m ediated
the therapeutic e ect of the drug in the patients disease?

A. Inhibition
of DNA-dependent RNA polym erase

B. Blockade
of the form ation of ribosom al initiation complex

C.&

A 49-year-old wom an on vacation in the
south of Italy presented w ith fever, headache, and a sm all, buttonlike skin
ulcer, 5 m m (about 0.2 inch) in diam eter, w ith a black center. The diagnosis
of Mediterranean spotted fever was m ade, and the wom an was prescribed
doxycycline. Which of the follow ing m olecular actions m ost likely m ediated
the therapeutic e ect of the drug in the patients disease?

A. Inhibition
of DNA-dependent RNA polym erase

B. Blockade
of the form ation of ribosom al initiation complex

C. Blockade
of transpeptidation reaction

D. Blockade
of binding of am inoacyl-transfer RNA (tRNA) to bacterial ribosom es

E. Inhibition
of transpeptidase enzym es

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