A 45-year-old wom an received a deceased-donor kidney transplant. Within 12 hours of the transplantation, she started im m unosuppressive pharm acotherapy that included cyclosporine. W hich of the follow ing actions m ost likely m ediated the therapeutic e ect of the drug in the patients disease? A. Stim ulation of synthesis of tum or necrosis factor B. Stim ulation of B-cell di erentiation into m em ory B cells C. Inhibition of the apoptosis pathway in target cells D. Stim ulation of gene expression for interleukin-2 production E. Inhibition of calcineurin enzym e
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