A 43-year-old m an w ith AIDS com plained to his physician of m ultiple painful ulcers on his tongue and palate. Exfoliative cytology led to the diagnosis of herpes sim plex infection, and therapy w ith oral acyclovir was initiated. Two weeks later, no im provem ent was seen, and the dose of the drug was increased, but w ithout success. Which of the follow ing was m ost likely the cause of failure of acyclovir therapy? A. Mutation of aspartate protease B. Viral transpeptidase de ciency C. Viral thym idine kinase de ciency D. Viral neuram inidase de ciency E. Mutation of reverse transcriptase
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