A 42-year-old m an w ith end-stage renal disease underwent a kidney transplant. Therapeutic m anagem ent of the patient included an intravenous injection of azathioprine just before surgery. Which of the follow ing m olecular actions m ost likely m ediated the im m unosuppressive e ect of the drug in this patient? A. Blockade of tum or necrosis factor-a (TNF-a) receptors B. Inhibition of clonal expansion of T and B lym phocytes C. Inhibition of antigen presentation by dendritic cells D. Stim ulation of genetic expression of interleukin-2 E. Stim ulation of m acrophage phagocytic activity
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