A 42-year-old HIV-positive w om an w as adm itted to the em ergency departm ent w ith the adm it ting diagnosis of pneum onia. Further exam s led to the diagnosis of cryptococcal pneum onia, and a treatm ent w ith liposom al am photericin B was started. Which of the follow ing best explains the prim ary advantage of liposom al preparations over the regular colloidal suspension of am photericin B? A. Decreased interactions w ith other drugs B. Increased antifungal activity spectrum C. Decreased system ic toxicit y D. Decreased drug clearance E. Increased oral bioavailability
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