A 41-year-old woman with a family history of hypothyroidism has her TSH checked during a routine…

A 41-year-old woman with a family history of hypothyroidism
has her TSH checked during a routine physical examination. Her TSH is 7.8 mU/L
(normal: _4.5 mU/L). She feels fine and denies any weight gain, fatigue,
cold intolerance, and dry skin. Further testing reveals normal circulating T4
and T3 levels but positive thyroid peroxidase (anti-TPO) autoantibodies.

Questions

A. What is the patient’s risk of progressing to overt hypothyroidism?

B. What are possible consequences of subclinical
hypothyroidism?

C. If her laboratory test values remain stable, and she
develops no new symptoms,
View complete question »

A 41-year-old woman with a family history of hypothyroidism
has her TSH checked during a routine physical examination. Her TSH is 7.8 mU/L
(normal: _4.5 mU/L). She feels fine and denies any weight gain, fatigue,
cold intolerance, and dry skin. Further testing reveals normal circulating T4
and T3 levels but positive thyroid peroxidase (anti-TPO) autoantibodies.

Questions

A. What is the patient’s risk of progressing to overt hypothyroidism?

B. What are possible consequences of subclinical
hypothyroidism?

C. If her laboratory test values remain stable, and she
develops no new symptoms, should she be treated?

View less »

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