1. A 35-year-old m an w ho underwent renal transplant showed signs of acute allograft rejection that

1. A 35-year-old m an w ho underwent renal transplant showed signs of acute allograft rejection that was resistant to corticosteroid treatm ent. He was treated w ith m urom onab-CD3 that was able to reverse the rejection. Which of the follow ing actions m ost likely m ediated the therapeutic e ect of the drug in the patients disease? A. Inhibition of antibody form ation by plasm a cells B. Inhibition of several enzym es involved in purine m etabolism C. Inhibition of calcineurin enzym e in T-cell cytoplasm D. Stim ulation of interleukin-1 synthesis in T cells E. Neutralization of a surface

1. A 35-year-old m an w ho underwent renal transplant showed signs of acute allograft rejection that was resistant to corticosteroid treatm ent. He was treated w ith m urom onab-CD3 that was able to reverse the rejection. Which of the follow ing actions m ost likely m ediated the therapeutic e ect of the drug in the patients disease? A. Inhibition of antibody form ation by plasm a cells B. Inhibition of several enzym es involved in purine m etabolism C. Inhibition of calcineurin enzym e in T-cell cytoplasm D. Stim ulation of interleukin-1 synthesis in T cells E. Neutralization of a surface protein receptor com plex in T cells

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